Neuroprotective potential of Zonisamide and Nigella sativa on traumatic brain injury-induced oxidative stress in mice

Traumatic brain injury (TBI) is a primary public health concern that has caused millions of deaths and disabilities around the world. Numerous medications are available to relieve TBI-associated complications, but they do not prevent further harm from occurring. As result, novel therapeutic medicines protect against neuronal damage as result trauma its repercussions, especially secondary injury, required. The study used Swiss albino mice (25-30 g) either sex. TBI was induced by weight-drop method. Oxidative stress parameters were observed following administration zonisamide (100 mg/kg) Nigella sativa (NS) (300 per se in combination. levels glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) significantly enhanced, malondialdehyde (MDA) Nitrite reduced treatment with mentioned drugs. results affirmed potential function both drugs preventing TBI-induced oxidative damage.